自然杀伤细胞与克氏锥虫感染的成纤维细胞之间的相互作用。
Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts.
作者信息
Lieke T, Steeg C, Graefe S E B, Fleischer B, Jacobs T
机构信息
Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
出版信息
Clin Exp Immunol. 2006 Aug;145(2):357-64. doi: 10.1111/j.1365-2249.2006.03118.x.
The protozoan parasite Trypanosoma cruzi circulates in the blood as trypomastigotes and invades a variety of cells to multiply intracellularly as amastigotes. The acute phase triggers an immune response that restricts the proliferation of the parasite. However, parasites are able to persist in different tissues causing the pathology of Chagas' disease. Natural killer (NK) cells play an important role in innate resistance to a variety of pathogens. In the present study we demonstrate that NK cells trigger trypanocidal mechanisms in infected L929 cells that are critically dependent on inducible nitric oxide (NO) synthase (iNOS) induction which is, to a major degree, triggered by interferon (IFN)-gamma provided by NK cells. This work provides a more detailed analysis of how NK cells as a part of the innate immune system participate in the control of parasites that reside intracellularly in fibroblast-like L929 cells.
原生动物寄生虫克氏锥虫以锥鞭毛体形式在血液中循环，并侵入多种细胞，以无鞭毛体形式在细胞内繁殖。急性期引发免疫反应，限制寄生虫的增殖。然而，寄生虫能够在不同组织中持续存在，导致恰加斯病的病理变化。自然杀伤（NK）细胞在对多种病原体的先天抵抗力中起重要作用。在本研究中，我们证明NK细胞在感染的L929细胞中触发杀锥虫机制，这主要依赖于诱导型一氧化氮（NO）合酶（iNOS）的诱导，而这在很大程度上是由NK细胞提供的干扰素（IFN）-γ触发的。这项工作更详细地分析了作为先天免疫系统一部分的NK细胞如何参与控制在成纤维细胞样L929细胞内寄生的寄生虫。
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