Costa A, Peppe A, Carlesimo G A, Pasqualetti P, Caltagirone C
I.R.C.C.S. Fondazione Santa Lucia, Roma, Italy.
Eur J Neurol. 2006 Aug;13(8):836-41. doi: 10.1111/j.1468-1331.2006.01216.x.
The authors investigated the possible relationship between depression and alexithymia in a population of hospitalized patients suffering from Parkinson's disease (PD). Fifty-eight PD patients without dementia participated in the study. Alexithymia was screened using the 20 item version of the Toronto Alexithymia Scale (TAS 20). Depression was diagnosed using a Structured Clinical Interview (SCID I) for DSM-IV. Severity of depression was evaluated with the Beck Depression Inventory (BDI). The prevalence of Alexithymia was about 21%. PD patients with major depression were significantly more alexithymic (TAS 20 average score = 61.4) than PD patients without depression (TAS 20 average score = 47.4) and, also, tended to be more alexithymic than PD patients with minor depression (MiD; TAS 20 average score =50.6), whereas no difference was found between PD patients with MiD and PD patients without depression. Moreover, high scores obtained on the BDI were found to strongly predict high level of alexithymia in these patients. These results extend to a cohort of PD patients previous data from the literature evidencing a strong association between alexithymia and severity of depressive symptoms.
作者在一群患有帕金森病（PD）的住院患者中研究了抑郁与述情障碍之间可能存在的关系。58名无痴呆的PD患者参与了该研究。使用多伦多述情障碍量表20项版本（TAS 20）筛查述情障碍。使用针对《精神疾病诊断与统计手册》第四版（DSM-IV）的结构化临床访谈（SCID I）诊断抑郁。用贝克抑郁量表（BDI）评估抑郁的严重程度。述情障碍的患病率约为21%。患有重度抑郁的PD患者比无抑郁的PD患者述情障碍程度明显更高（TAS 20平均得分 = 61.4），并且也比患有轻度抑郁（MiD）的PD患者述情障碍程度更高（TAS 20平均得分 = 50.6），而患有MiD的PD患者与无抑郁的PD患者之间未发现差异。此外，发现这些患者在BDI上获得的高分强烈预测了述情障碍的高水平。这些结果扩展到了一组PD患者，此前文献数据表明述情障碍与抑郁症状严重程度之间存在密切关联。
