Rebell G, Rywlin A, Haines H
Am J Vet Res. 1975 Aug;36(08):1221-4.
Nine successive groups of green sea turtles (Chelonia mydas) were observed in aquaculture during the posthatchling period. During the first 6 months of growth, each group underwent an epizootic of skin lesions, named gray-patch disease. Two types of skin lesions are associated with gray-patch disease: papules and, more characteristically, spreading gray patches which appear 7 to 8 weeks after hatching. In both types of lesions, intranuclear inclusions are found in keratinocytes in the malpighian layer of the epidermis. Electron microscopic examination of scrapings from lesions and biopsies revealed many viral particles, with features characteristic of the herpesvirus group. Transmission of gray-patch disease is possible with bacteria-free preparations of viral particles.
在孵化后阶段，对九组连续的绿海龟（蠵龟）进行了水产养殖观察。在生长的前6个月里，每组海龟都经历了一场皮肤病疫情，称为灰斑病。与灰斑病相关的有两种皮肤损伤：丘疹，更典型的是在孵化7至8周后出现的扩散性灰斑。在这两种损伤类型中，均可在表皮马尔皮基层的角质形成细胞中发现核内包涵体。对损伤部位的刮屑和活检组织进行电子显微镜检查，发现了许多病毒颗粒，具有疱疹病毒组的特征。用无细菌的病毒颗粒制剂可传播灰斑病。
