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病毒-宿主协同进化,重点关注动物和人类 DNA 病毒。

Virus-Host Coevolution with a Focus on Animal and Human DNA Viruses.

机构信息

Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest, 1143, Hungary.

出版信息

J Mol Evol. 2020 Jan;88(1):41-56. doi: 10.1007/s00239-019-09913-4. Epub 2019 Oct 10.

Abstract

Viruses have been infecting their host cells since the dawn of life, and this extremely long-term coevolution gave rise to some surprising consequences for the entire tree of life. It is hypothesised that viruses might have contributed to the formation of the first cellular life form, or that even the eukaryotic cell nucleus originates from an infection by a coated virus. The continuous struggle between viruses and their hosts to maintain at least a constant fitness level led to the development of an unceasing arms race, where weapons are often shuttled between the participants. In this literature review we try to give a short insight into some general consequences or traits of virus-host coevolution, and after this we zoom in to the viral clades of adenoviruses, herpesviruses, nucleo-cytoplasmic large DNA viruses, polyomaviruses and, finally, circoviruses.

摘要

病毒自生命诞生之初便感染宿主细胞,这种极其漫长的共同进化为整个生命之树带来了一些惊人的后果。据推测,病毒可能促成了最初的细胞生命形式的形成,甚至真核细胞的细胞核也起源于被有衣壳病毒的感染。病毒与其宿主之间为维持至少恒定适应度水平而持续斗争,导致了一场持续不断的军备竞赛,而武器常常在参与者之间来回传递。在这篇文献综述中,我们试图简要介绍一下病毒-宿主共同进化的一些普遍后果或特征,然后再聚焦于腺病毒、疱疹病毒、核质大 DNA 病毒、多瘤病毒和环状病毒等病毒类群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f9e/6943099/fd5afde44f1f/239_2019_9913_Fig1_HTML.jpg

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