含2,4-二氯-5-氟苯基部分的席夫碱和曼尼希碱的合成及生物活性
Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.
作者信息
Karthikeyan Mari Sithambaram, Prasad Dasappa Jagadeesh, Poojary Boja, Subrahmanya Bhat K, Holla Bantwal Shivarama, Kumari Nalilu Suchetha
机构信息
Department of Chemistry, Mangalore University, Mangalagangothri 574199, India.
出版信息
Bioorg Med Chem. 2006 Nov 15;14(22):7482-9. doi: 10.1016/j.bmc.2006.07.015. Epub 2006 Aug 1.
A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.
通过用甲醛和仲胺/取代伯胺进行氨甲基化反应，从三唑席夫碱（3）制备了一系列带有2,4-二氯-5-氟苯基的曼尼希碱（4和5）。对所有新合成的化合物进行了抗菌活性筛选。化合物3c、4c、4e和4f表现出良好的抗菌活性，化合物3c、5c、5e和5f表现出良好的抗真菌活性。
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