Tsacheva Ivelina, Todorova Zornica, Momekova Denitsa, Momekov Georgi, Koseva Neli
Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, 1113 Sofia, Bulgaria.
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Pharmaceuticals (Basel). 2023 Jun 28;16(7):938. doi: 10.3390/ph16070938.
This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely, potent candidates with antibacterial and antifungal activity, antioxidant and chemosensing properties. These advantageous properties are enhanced upon metal complexing. The subject of the review has been extended with a brief discussion on reactivity of Schiff bases with hydrogen phosphonates and the preparation of low and high molecular phosphonates, as well as their application as pharmacological agents. This work will be of interest for scientists seeking new challenges in discovering advanced pharmacological active molecules gaining inspiration from the versatile families of imines and aminophosphonates.
这篇综述论文聚焦于含蒽和呋喃的席夫碱的设计及其作为配合过渡金属离子的配体的先进性质。该论文还简要概述了各种生物应用，即具有抗菌和抗真菌活性、抗氧化和化学传感性质的潜在候选物。这些有利性质在金属络合后会增强。综述主题还扩展到席夫碱与氢膦酸酯的反应性以及低分子和高分子膦酸酯的制备，以及它们作为药物制剂的应用。这项工作将引起那些从亚胺和氨基膦酸酯的多功能家族中获得灵感、寻求发现先进药理活性分子新挑战的科学家的兴趣。
