甲状腺髓样癌

Medullary thyroid cancer.

作者信息

You Y Nancy, Lakhani Vipul, Wells Samuel A, Moley Jeffrey F

机构信息

Department of Surgery, Mayo Clinic, Gonda 12, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Surg Oncol Clin N Am. 2006 Jul;15(3):639-60. doi: 10.1016/j.soc.2006.05.008.

DOI:10.1016/j.soc.2006.05.008

PMID:16882502

Abstract

The goal in managing patients who have MTC is to detect and surgically remove disease at an early stage. Tumor marker-based biochemical screening and DNA-based genetic screening have created the opportunity for effective prophylactic surgery in patients at risk for hereditary MTC. Complete surgical resection is critical for cure because cervical reoperation for persistent or recurrent disease benefits only select patients. With the advent of therapies that target the RET-activated pathways, new hope may be emerging for patients who have locally advanced or metastatic disease.

摘要

管理甲状腺髓样癌（MTC）患者的目标是在疾病早期进行检测并通过手术切除病灶。基于肿瘤标志物的生化筛查和基于DNA的基因筛查为遗传性MTC高危患者进行有效的预防性手术创造了机会。完整的手术切除对于治愈至关重要，因为针对持续性或复发性疾病进行颈部再次手术仅对部分患者有益。随着针对RET激活通路的治疗方法的出现，局部晚期或转移性疾病患者可能迎来新的希望。