Telkova I L, Tepliakov A T, Karpov R S
Kardiologiia. 2006;46(6):43-8.
Changes of blood insulin content were studied in patients with ischemic heart disease with various functional classes of acute and chronic heart failure and at different disease stages. It was established that latent hyperinsulinemia which became evident at induced myocardial ischemia was present on all stages of development of ischemic heart disease. In acute heart failure due to developed myocardial infarction hyperinsulinemia manifested in 58.3% of patients. Amount of insulin in blood increased almost 3 times. During progression of chronic heart failure insulin content significantly decreased, probably because of exhaustion of insulin producing function and development of its relative or absolute deficit. At terminal stage of congestive heart failure insulin level was < or = 1 microU/ml. The authors believe that severity of clinical signs of acute and chronic heart failure are determined by sensitivity of myocardium to insulin, content of insulin in blood, and also depends on compensatory possibilities of insulin producing function at each stage of development of the disease.
对患有不同功能分级的急性和慢性心力衰竭且处于不同疾病阶段的缺血性心脏病患者的血液胰岛素含量变化进行了研究。结果表明，在缺血性心脏病发展的各个阶段均存在潜在的高胰岛素血症，这种高胰岛素血症在诱发心肌缺血时变得明显。在因心肌梗死导致的急性心力衰竭中，58.3%的患者出现高胰岛素血症。血液中的胰岛素含量几乎增加了3倍。在慢性心力衰竭进展过程中，胰岛素含量显著下降，这可能是由于胰岛素分泌功能衰竭及其相对或绝对缺乏的发展所致。在充血性心力衰竭终末期，胰岛素水平≤1微单位/毫升。作者认为，急性和慢性心力衰竭临床症状的严重程度取决于心肌对胰岛素的敏感性、血液中胰岛素的含量，还取决于疾病发展各阶段胰岛素分泌功能的代偿可能性。
