Richardson P M
Division of Neurosurgery, Montreal General Hospital, Canada.
Curr Opin Neurobiol. 1991 Oct;1(3):401-6. doi: 10.1016/0959-4388(91)90061-b.
Nerve growth factor, fibroblast growth factor, and ciliary neurotrophic factor can protect selected populations of neurons from some of the degenerative changes that otherwise follow axonal injury or other insults. The function of diffusible neurotrophic factors in axonal regeneration is still unclear, however. Knowledge of the nerve growth factor congeners, brain-derived neurotrophic factor and neurotrophin-3, is advancing rapidly as is the identification of neurotrophin receptors, several of which are membrane-bound tyrosine kinases.
神经生长因子、成纤维细胞生长因子和睫状神经营养因子可以保护特定的神经元群体，使其免受一些在轴突损伤或其他损伤后可能出现的退行性变化。然而，可扩散神经营养因子在轴突再生中的功能仍不清楚。随着神经营养因子受体（其中几种是膜结合酪氨酸激酶）的鉴定，对神经生长因子同类物、脑源性神经营养因子和神经营养素-3的认识正在迅速发展。
