Lu Liang-ping, Li Xing-wang, Liu Ying, Sun Guo-chang, Chen Zhi-hai, Zhu Xi-lin, Hu Quan-you, Li Hui
Department of Epidemiology & Statistics, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Aug;23(4):427-30.
To assess the association of haplotype of HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection in Han population of north China.
Two hundred and seven chronic hepatitis B (HB) patients, two hundred and twelve chronic asymptomatic hepatitis B virus (HBV) carriers (HBV carrier) and one hundred and forty-eight self-limited HBV infection were investigated for HLA-DRB1 and HLA-DQA1 alleles by sequence specific-polymerase chain reaction (PCR-SSP).
The frequency of DRB104-DQA10301 haplotype was 10.03% in self-limited HBV infection subjects, significantly higher than that in chronic HB patients (3.66%) (P=0.0005)ûthe frequency of DRB115/16-DQA10102 haplotype was 6.80% in self-limited HBV infection subjects, significantly higher than 1.94% in chronic HB patients (P=0.0012) and 1.65% in asymptomatic HBV carriers (P=0.0004)ûwhile the frequency of DRB104-DQA1*0302 haplotype was 3.10% in chronic HB patients, higher than that in self-limited HBV infection subjects (0.39%) (P=0.0077).
Individuals with different haplotypes composed of HLA-DRB1 and HLA-DQA1 might have different outcomes of HBV infection.
评估中国北方汉族人群中HLA - DRB1单倍型和HLA - DQA1等位基因与乙型肝炎病毒感染结局的关联。
采用序列特异性聚合酶链反应（PCR - SSP）对207例慢性乙型肝炎（CHB）患者、212例慢性无症状乙型肝炎病毒（HBV）携带者及148例自限性HBV感染者进行HLA - DRB1和HLA - DQA1等位基因检测。
自限性HBV感染组中DRB104 - DQA10301单倍型频率为10.03%，显著高于慢性乙型肝炎患者组（3.66%）（P = 0.0005）；自限性HBV感染组中DRB115/16 - DQA10102单倍型频率为6.80%，显著高于慢性乙型肝炎患者组的1.94%（P = 0.0012）及无症状HBV携带者组的1.65%（P = 0.0004）；而慢性乙型肝炎患者组中DRB104 - DQA1*0302单倍型频率为3.10%，高于自限性HBV感染组（0.39%）（P = 0.0077）。
由HLA - DRB1和HLA - DQA1组成的不同单倍型个体可能具有不同的HBV感染结局。
