Agee Kelli A, Becker Thomas D, Joyce Anthony P, Rueggeberg Frederick A, Borke James L, Waller Jennifer L, Tay Franklin R, Pashley David H
Department of Oral Biology & Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, USA.
J Biomed Mater Res A. 2006 Nov;79(2):349-58. doi: 10.1002/jbm.a.30752.
The purpose of this work was to determine if nonaqueous methacrylate monomer/alcohol mixtures could expand dried collapsed demineralized dentin matrix. Thin disks (ca. 200 microm) of human dentin were demineralized and placed in wells beneath contact probes of linear variable differential transformers. The probes were placed on water-saturated expanded matrices to record the shrinkage associated with drying. Monomer mixtures containing hydroxyethyl methacrylate, 2,2-bis[4-(2-hydroxy-3 methacryloyloxy)propoxyphenyl] propane, or triethyleneglycol dimethacrylate were mixed with methanol or ethanol at alcohol/monomer mass fraction % of 90/10, 70/30, 50/50, or 30/70. They were randomly applied to the dried matrices to determine the rate and magnitude of expansion; then shrinkage was recorded during evaporation of the alcohols. The results indicated that matrix expansion was positively correlated with the Hoy's solubility parameters for hydrogen bonding forces (delta(h)) of the monomer/solvent mixtures (p < 0.001). Expansions were more rapid with methanol-containing than with ethanol-containing monomer mixtures. For the test solutions, triethyleneglycol dimethacrylate-containing mixtures produced the slowest rate of matrix expansion and hydroxyethyl methacrylate-containing mixtures the most rapid expansion. When the solvents were evaporated, the matrix shrank in proportion to the solvent content and the delta(h) of the monomer-solvent mixtures. The results indicate that expansion of dried, collapsed dentin matrices requires that the delta(h) of the mixtures be larger than 17 (J/cm(3))(1/2). The greater the delta(h) of the monomer solutions, the greater the rate and extent of expansion.
本研究的目的是确定非水甲基丙烯酸酯单体/醇混合物是否能使干燥塌陷的脱矿牙本质基质膨胀。将人牙本质薄片（约200微米）脱矿后置于线性可变差动变压器接触探头下方的孔中。探头放置在水饱和的膨胀基质上，以记录与干燥相关的收缩情况。将含有甲基丙烯酸羟乙酯、2,2-双[4-(2-羟基-3-甲基丙烯酰氧基)丙氧基苯基]丙烷或三乙二醇二甲基丙烯酸酯的单体混合物与甲醇或乙醇按醇/单体质量分数90/10、70/30、50/50或30/70混合。将它们随机应用于干燥的基质上，以确定膨胀速率和幅度；然后在醇蒸发过程中记录收缩情况。结果表明，基质膨胀与单体/溶剂混合物的氢键力Hoy溶解度参数（δ(h)）呈正相关（p < 0.001）。含甲醇的单体混合物比含乙醇的单体混合物膨胀更快。对于测试溶液，含三乙二醇二甲基丙烯酸酯的混合物产生的基质膨胀速率最慢，而含甲基丙烯酸羟乙酯的混合物膨胀最快。当溶剂蒸发时，基质收缩与溶剂含量和单体-溶剂混合物的δ(h)成比例。结果表明，干燥塌陷的牙本质基质膨胀要求混合物的δ(h)大于17（J/cm³）¹/²。单体溶液的δ(h)越大，膨胀速率和程度越大。
