Becker Thomas D, Agee Kelli A, Joyce Anthony P, Rueggeberg Frederick A, Borke James L, Waller Jennifer L, Tay Franklin R, Pashley David H
U.S. Army DENTAC, Fort Gordon, Georgia, USA.
J Biomed Mater Res B Appl Biomater. 2007 Jan;80(1):156-65. doi: 10.1002/jbm.b.30580.
During dentin bonding, solvated adhesive comonomers are applied to water-saturated decalcified dentin matrices. When alcohol-solvated hydrophilic or hydrophobic methacrylate monomers are applied, they chemically remove water and cause matrix shrinkage during comonomer infiltration. Evaporation of solvent induces further shrinkage. The purpose of this work was to compare the shrinkage of water-saturated dentin matrices infiltrated with ethanol- or methanol-solvated 2-hydroxyethyl methacrylate (HEMA), 2,2-bis[4(2-hydroxy-3-methacryloyloxy-propyloxy)-phenyl] propane (BisGMA), or triethyleneglycol dimethacrylate (TEGDMA) at 90/10, 70/30, 50/50, and 30/70 mass fraction % alcohol/monomer before and after evaporation of alcohol. Thin (ca 0.2 mm) disks of human mid-coronal dentin were demineralized and placed in a well beneath the contact probe of a linear variable differential transformer (LVDT). The height of the matrix was measured before and after random application of one of the twelve alcohol/monomer mixtures. Matrix height was measured during infiltration and during solvent evaporation. Between trials, residual monomer was extracted using ethanol. These studies were repeated on specimens in which 100% alcohol was used to substitute for water in the matrix. Both studies revealed that matrices shrink 30-50% but that pretreatment of matrices with alcohol prevents BisGMA phase separations from occurring. Wet bonding with ethanol instead of water permits infiltration of relatively hydrophobic alcohol/monomers.
在牙本质粘结过程中，将溶剂化的粘结共聚单体应用于水饱和的脱矿牙本质基质。当应用醇溶剂化的亲水性或疏水性甲基丙烯酸酯单体时，它们会化学去除水分并在共聚单体渗透过程中导致基质收缩。溶剂蒸发会引起进一步收缩。本研究的目的是比较用乙醇或甲醇溶剂化的甲基丙烯酸2-羟乙酯（HEMA）、双酚A双甲基丙烯酸缩水甘油酯（BisGMA）或三乙二醇二甲基丙烯酸酯（TEGDMA）在90/10、70/30、50/50和30/70质量分数%的醇/单体比例下对水饱和牙本质基质进行浸润，在醇蒸发前后的收缩情况。将人牙中冠部的薄（约0.2毫米）牙本质盘脱矿，并放置在线性可变差动变压器（LVDT）接触探头下方的孔中。在随机施加十二种醇/单体混合物之一之前和之后测量基质的高度。在浸润过程和溶剂蒸发过程中测量基质高度。在试验之间，用乙醇提取残留单体。对用100%醇替代基质中的水的标本重复这些研究。两项研究均表明，基质收缩30 - 50%，但用醇对基质进行预处理可防止BisGMA相分离的发生。用乙醇而非水进行湿粘结可使相对疏水的醇/单体得以浸润。
