Roses A D, Butterfield A, Appel S H, Chestnut D B
Arch Neurol. 1975 Aug;32(8):535-8. doi: 10.1001/archneur.1975.00490500055006.
Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin (formerly diphenylhydantoin) "normalizes" fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.
电子自旋共振光谱法被用于证实强直性红细胞中存在膜缺陷。强直性细胞膜的膜流动性增加且极性降低。苯妥英（以前称为二苯乙内酰脲）可“使”来自强直性红细胞的光谱中的流动性差异“正常化”，但对正常光谱无显著影响。这些实验证明了生物物理方法在人类红细胞膜上的适用性，并支持强直性肌营养不良中存在膜缺陷的概念，该缺陷并非由原发性肌病、神经病或血管病引起。
