Janát-Amsbury Margit Maria, Yockman James William, Anderson Matthew Linley, Kieback Dirk Günter, Kim Sung Wan
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Baylor College of Medicine, Dryden Rd., Suite 1100, Houston, Texas 77030, USA.
Anticancer Res. 2006 Jul-Aug;26(4B):2785-9.
Attempts to develop novel immunotherapeutic mouse models have been hampered by the lack of an adequate in vivo system. This study was performed to establish an immunocompetent mouse model for the testing of immunotherapy concepts. The in vivo system was based on a svngeneic mouse ovarian surface epithelium (MOSE) cancer, physiologically and biologically closely resembling human epithelial ovarian cancer. In addition, a more aggressive variant containing a mutated form of vascular epithelial growth factor was also evaluated. The growth patterns of these ovarian cancer cells in mice were compared to the established, highly aggressive 4T1 breast cancer model. A clinically-relevant tool for the study of different growth patterns in ovarian cancer, with potential significance for the development of novel immunological methods, was successfully developed.
开发新型免疫治疗小鼠模型的尝试因缺乏合适的体内系统而受阻。本研究旨在建立一种免疫健全的小鼠模型，用于测试免疫治疗概念。该体内系统基于同基因小鼠卵巢表面上皮（MOSE）癌，在生理和生物学上与人类上皮性卵巢癌极为相似。此外，还评估了一种含有血管内皮生长因子突变形式的更具侵袭性的变体。将这些卵巢癌细胞在小鼠体内的生长模式与已建立的、高度侵袭性的4T1乳腺癌模型进行了比较。成功开发出一种临床上相关的工具，用于研究卵巢癌的不同生长模式，对新型免疫方法的开发具有潜在意义。
