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环磷酸鸟苷（cGMP）诱导的视杆细胞外段质膜中环磷酸鸟苷依赖性电导的失活

Inactivation of cGMP-dependent conductance of rod outer segment plasma membrane induced by cGMP.

作者信息

Zhainazarov A B, Kolesnikov S S

机构信息

Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region.

出版信息

FEBS Lett. 1990 Jan 15;260(1):149-51. doi: 10.1016/0014-5793(90)80089-2.

DOI:10.1016/0014-5793(90)80089-2
PMID:1688810
Abstract

Integral cGMP-dependent currents as well as activity of single cGMP-activated channels in plasma membrane of rod outer segment (ROS) were recorded using the patch-clamp method. The dependence of integral currents on cGMP concentration is shown to be bell-shaped. Decrease in cGMP-dependent conductance at high cGMP concentration results from a decrease in channel opening probability. Thus, cGMP in high concentrations inactivates cGMP-dependent conductance.

摘要

使用膜片钳方法记录了视杆外段（ROS）质膜中完整的环鸟苷酸（cGMP）依赖性电流以及单个cGMP激活通道的活性。完整电流对cGMP浓度的依赖性呈钟形。高cGMP浓度下cGMP依赖性电导的降低是由于通道开放概率的降低。因此，高浓度的cGMP会使cGMP依赖性电导失活。

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