Kolesnikov S S, Jainazarov A B, Fesenko E E
Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region.
FEBS Lett. 1987 Sep 28;222(1):37-41. doi: 10.1016/0014-5793(87)80187-4.
cGMP markedly increases the cationic conductance of the 'inside-out' patches of rod outer segment plasma membrane when applied to the inner side. The cGMP-activated conductance of some patches was shown to be time-dependent. The data obtained suggest that the change of cGMP concentration in the near membrane layer underlies this phenomenon rather than the change in the channel's activity. The hydrolysis and, probably, the desorption of the nucleotide are responsible for this.
