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人类免疫相关鸟苷三磷酸酶诱导自噬以清除细胞内分枝杆菌。

Human IRGM induces autophagy to eliminate intracellular mycobacteria.

作者信息

Singh Sudha B, Davis Alexander S, Taylor Gregory A, Deretic Vojo

机构信息

Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.

出版信息

Science. 2006 Sep 8;313(5792):1438-41. doi: 10.1126/science.1129577. Epub 2006 Aug 3.

DOI:10.1126/science.1129577
PMID:16888103
Abstract

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

摘要

免疫相关的p47鸟苷三磷酸酶（IRG）在抵御细胞内病原体方面发挥作用。我们发现，小鼠Irgm1（LRG - 47）鸟苷三磷酸酶可诱导自噬并产生大型自噬溶酶体细胞器，作为消除细胞内结核分枝杆菌的一种机制。我们还确定了一种人类IRG蛋白在控制细胞内病原体方面的功能，并报告说人类Irgm1直系同源物IRGM在自噬和降低细胞内细菌载量方面发挥作用。

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