Babai Norbert, Atlasz Tamas, Tamás Andrea, Reglodi Dora, Tóth Gabor, Kiss Peter, Gábriel Robert
Department of Experimental Zoology and Neurobiology, University of Pécs, 7624 Pécs, Hungary.
Ann N Y Acad Sci. 2006 Jul;1070:149-55. doi: 10.1196/annals.1317.003.
We have previously shown the protective effects of pituitary adenylate cyclaseactivating polypeptide (PACAP) in monosodium glutamate (MSG)-induced retinal degeneration. In the present article, we have investigated the optimal model for examining this neuroprotective effect. One MSG treatment on postnatal (P) days 1 or 5, in spite of leading to same ultrastructural changes, does not cause enough damage to study neuroprotection. When retinas were treated three times with MSG, the entire inner retina degenerated. Neuroprotection with PACAP was achieved with at least two treatments. Evidence suggests that PACAP provides protection against excitotoxicity, therefore, it may be a useful agent in reducing excitotoxic damage in the retina.
我们之前已经证明垂体腺苷酸环化酶激活多肽（PACAP）对谷氨酸单钠（MSG）诱导的视网膜变性具有保护作用。在本文中，我们研究了用于检测这种神经保护作用的最佳模型。尽管出生后（P）第1天或第5天进行一次MSG处理会导致相同的超微结构变化，但不会造成足够的损伤来研究神经保护作用。当用MSG对视网膜进行三次处理时，整个视网膜内层发生变性。用PACAP进行神经保护至少需要两次处理。有证据表明，PACAP可提供针对兴奋性毒性的保护作用，因此，它可能是减轻视网膜兴奋性毒性损伤的有用药物。
