Department of Anatomy, University of Pecs, 7624 Pecs, Szigeti u 12, Hungary.
Neurosci Lett. 2011 Jan 10;487(3):400-5. doi: 10.1016/j.neulet.2010.10.065. Epub 2010 Nov 2.
Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors occur throughout the nervous system, including the retina. PACAP exerts diverse actions in the eye: it influences ocular blood flow, contraction of the ciliary muscle, and has retinoprotective effects. This effect has been proven in different models of retinal degeneration. We have previously shown that PACAP protects against monosodium-glutamate (MSG)-induced damage in neonatal rats. The beneficial effects of enriched environment, another neuroprotective strategy, have long been known. Environmental enrichment has been shown to decrease different neuronal injuries. It also influences the development of the visual system. We have recently demonstrated that significant neuroprotection can be achieved in MSG-induced retinal degeneration in animals kept in an enriched environment. Combination of neuroprotective strategies often results in increased protection. Therefore, the aim of the present study was to compare the two neuroprotective strategies alone and in combination therapy. We found that both PACAP and environmental enrichment led to a similar degree of retinal protection, but the two treatments together did not lead to increased protection: their effects were not additive.
垂体腺苷酸环化酶激活肽（PACAP）及其受体存在于整个神经系统中，包括视网膜。PACAP 在眼睛中发挥多种作用：它影响眼血流、睫状肌收缩，并具有视网膜保护作用。这种作用已在不同的视网膜变性模型中得到证实。我们之前曾表明，PACAP 可预防新生大鼠的单谷氨酸钠（MSG）诱导的损伤。丰富环境的有益效果，另一种神经保护策略，早已为人所知。丰富的环境已被证明可以减少不同的神经元损伤。它还会影响视觉系统的发育。我们最近证明，在富含环境的动物中，MSG 诱导的视网膜变性可以实现显著的神经保护。联合使用神经保护策略通常会增加保护。因此，本研究的目的是比较两种神经保护策略单独和联合治疗的效果。我们发现，PACAP 和环境富集都导致了类似程度的视网膜保护，但两种治疗方法一起并没有增加保护：它们的效果不是累加的。
