短期禁食会使大鼠和鸡大脑中的垂体腺苷酸环化酶激活肽（PACAP）和血管活性肠肽（VIP）水平发生不同变化。

Short-term fasting differentially alters PACAP and VIP levels in the brains of rat and chicken.

作者信息

Jozsa Rita, Nemeth Jozsef, Tamas Andrea, Hollosy Tibor, Lubics Andrea, Jakab Balazs, Olah Andras, Lengvari Istvan, Arimura Akira, Reglödi Dora

机构信息

Department of Anatomy, Neurohumoral Regulations Research Group of the Hungarian Academy of Sciences, University of Pécs, 7624 Pécs, Szigeti u 12. Hungary.

出版信息

Ann N Y Acad Sci. 2006 Jul;1070:354-8. doi: 10.1196/annals.1317.044.

DOI:10.1196/annals.1317.044

PMID:16888191

Abstract

The present article investigated the levels of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) in the brains of rats and chickens 12, 36, and 84 h after starvation. PACAP levels increased in both species, 12 h after food deprivation in rats, and with a 24-h delay in chickens. VIP levels showed a more complex pattern: a gradual increase in the hypothalamus and telencephalon, and a significant decrease in the brain stem of rats. In chickens, a decrease was observed in every brain area after 36 h of starvation. These data show that PACAP and VIP are differentially regulated and are involved in the regulatory processes under a food-restricted regimen, and are differentially altered in nocturnal and diurnal species.

摘要

本文研究了饥饿12小时、36小时和84小时后大鼠和鸡大脑中垂体腺苷酸环化酶激活多肽（PACAP）和血管活性肠肽（VIP）的水平。大鼠禁食12小时后，两种物种的PACAP水平均升高，鸡则延迟24小时升高。VIP水平呈现出更复杂的模式：大鼠下丘脑和端脑中逐渐升高，而脑干中显著降低。在鸡中，饥饿36小时后每个脑区均出现降低。这些数据表明，PACAP和VIP受到不同的调节，参与食物限制方案下的调节过程，并且在夜行性和昼行性物种中发生不同的变化。