促胰液素、垂体腺苷酸环化酶激活肽和胰高血糖素肽家族对摄食行为的中枢控制
Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides.
作者信息
Sekar Revathi, Wang Lei, Chow Billy Kwok Chong
机构信息
School of Biological Sciences, The University of Hong Kong , Hong Kong , China.
出版信息
Front Endocrinol (Lausanne). 2017 Feb 7;8:18. doi: 10.3389/fendo.2017.00018. eCollection 2017.
Abstract
Constituting a group of structurally related brain-gut peptides, secretin (SCT), pituitary adenylate cyclase-activating peptide (PACAP), and glucagon (GCG) family of peptide hormones exert their functions interactions with the class B1 G protein-coupled receptors. In recent years, the roles of these peptides in neuroendocrine control of feeding behavior have been a specific area of research focus for development of potential therapeutic drug targets to combat obesity and metabolic disorders. As a result, some members in the family and their analogs have already been utilized as therapeutic agents in clinical application. This review aims to provide an overview of the current understanding on the important role of SCT, PACAP, and GCG family of peptides in central control of feeding behavior.
摘要
促胰液素（SCT）、垂体腺苷酸环化酶激活肽（PACAP）和胰高血糖素（GCG）属于一组结构相关的脑肠肽，这类肽激素通过与B1类G蛋白偶联受体相互作用来发挥其功能。近年来，这些肽在进食行为的神经内分泌控制中的作用已成为一个特定的研究重点领域，旨在开发对抗肥胖和代谢紊乱的潜在治疗药物靶点。因此，该家族中的一些成员及其类似物已在临床应用中用作治疗药物。本综述旨在概述目前对SCT、PACAP和GCG肽家族在进食行为中枢控制中的重要作用的理解。
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