Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction.
作者信息
Liao James K
出版信息
Circ Res. 2006 Aug 4;99(3):238-9. doi: 10.1161/01.RES.0000236798.01988.5d.
Abstract
摘要
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1
Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction.Rho激酶：高胆固醇血症与血管平滑肌异常收缩之间的潜在联系。
Circ Res. 2006 Aug 4;99(3):238-9. doi: 10.1161/01.RES.0000236798.01988.5d.
2
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.胆固醇使血管平滑肌致敏，以诱导由鞘氨醇磷酸胆碱- Rho激酶途径介导的Ca2+敏感性增加：膜筏的可能作用。
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[Novel mechanisms for increasing Ca2+ sensitivity of contractile apparatus in smooth muscle].
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Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.鞘氨醇磷酸胆碱是牛脑动脉中Rho激酶介导的Ca2+ 致敏的新型信使：蛋白激酶C作用不大。
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本文引用的文献
1
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.胆固醇使血管平滑肌致敏，以诱导由鞘氨醇磷酸胆碱- Rho激酶途径介导的Ca2+敏感性增加：膜筏的可能作用。
Circ Res. 2006 Aug 4;99(3):299-306. doi: 10.1161/01.RES.0000235877.33682.e9. Epub 2006 Jul 6.
2
Physiological role of ROCKs in the cardiovascular system.ROCKs在心血管系统中的生理作用。
Am J Physiol Cell Physiol. 2006 Mar;290(3):C661-8. doi: 10.1152/ajpcell.00459.2005.
3
Rho GTPases, statins, and nitric oxide.Rho鸟苷三磷酸酶、他汀类药物与一氧化氮
Circ Res. 2005 Dec 9;97(12):1232-5. doi: 10.1161/01.RES.0000196564.18314.23.
4
Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA).血压及其他变量在盎格鲁-斯堪的纳维亚心脏结局试验-降压组（ASCOT-BPLA）中所观察到的心血管事件发生率差异中的作用。
Lancet. 2005;366(9489):907-13. doi: 10.1016/S0140-6736(05)67186-3.
5
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.抑制Rho激酶（ROCK）可增加脑血流量并起到中风保护作用。
Stroke. 2005 Oct;36(10):2251-7. doi: 10.1161/01.STR.0000181077.84981.11. Epub 2005 Sep 1.
6
Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice.Rho相关蛋白激酶促进小鼠早期动脉粥样硬化病变形成。
Circ Res. 2003 Oct 31;93(9):884-8. doi: 10.1161/01.RES.0000099062.55042.9A. Epub 2003 Oct 2.
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Rocks: multifunctional kinases in cell behaviour.ROCKs：细胞行为中的多功能激酶
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Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.在盎格鲁-斯堪的纳维亚心脏结局试验——降脂分支（ASCOT-LLA）中，阿托伐他汀对胆固醇浓度处于平均水平或低于平均水平的高血压患者冠心病和中风事件的预防作用：一项多中心随机对照试验。
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Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.Rho激酶抑制剂法舒地尔对变异性心绞痛患者冠状动脉痉挛的抑制作用
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Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.Rho激酶可能参与人类高血压的发病机制。
Hypertension. 2001 Dec 1;38(6):1307-10. doi: 10.1161/hy1201.096541.
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