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Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction.Rho激酶：高胆固醇血症与血管平滑肌异常收缩之间的潜在联系。
Circ Res. 2006 Aug 4;99(3):238-9. doi: 10.1161/01.RES.0000236798.01988.5d.
2
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.胆固醇使血管平滑肌致敏，以诱导由鞘氨醇磷酸胆碱- Rho激酶途径介导的Ca2+敏感性增加：膜筏的可能作用。
Circ Res. 2006 Aug 4;99(3):299-306. doi: 10.1161/01.RES.0000235877.33682.e9. Epub 2006 Jul 6.
3
Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells.II类磷酸肌醇3激酶α亚型在Ca2+诱导的、Rho和Rho激酶依赖性调节分离的血管平滑肌细胞中肌球蛋白磷酸酶和收缩方面的重要作用。
Mol Pharmacol. 2007 Mar;71(3):912-20. doi: 10.1124/mol.106.032599. Epub 2006 Dec 19.
4
[Novel mechanisms for increasing Ca2+ sensitivity of contractile apparatus in smooth muscle].
Masui. 1998 May;47(5):530-40.
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Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction.G(12)/G(13)在激动剂诱导的血管平滑肌细胞收缩中的作用。
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Circ Res. 2003 Sep 19;93(6):548-56. doi: 10.1161/01.RES.0000090998.08629.60. Epub 2003 Aug 14.
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Microtubule depolymerization facilitates contraction of vascular smooth muscle via increased activation of RhoA/Rho-kinase.微管解聚通过增强RhoA/ Rho激酶的激活促进血管平滑肌收缩。
Med Hypotheses. 2001 Mar;56(3):381-5. doi: 10.1054/mehy.2000.1207.
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The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction.RhoA及Rho相关激酶在血管平滑肌收缩中的作用。
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10
Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C.鞘氨醇磷酸胆碱是牛脑动脉中Rho激酶介导的Ca2+ 致敏的新型信使：蛋白激酶C作用不大。
Circ Res. 2002 Jul 26;91(2):112-9. doi: 10.1161/01.res.0000026057.13161.42.

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1
Rho kinase inhibitor fasudil mitigates high-cholesterol diet-induced hypercholesterolemia and vascular damage.Rho激酶抑制剂法舒地尔可减轻高胆固醇饮食诱导的高胆固醇血症和血管损伤。
Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):409-422. doi: 10.1007/s00210-017-1343-x. Epub 2017 Jan 18.
2
Testosterone and cholesterol vasodilation of rat aorta involves L-type calcium channel inhibition.睾酮与大鼠主动脉胆固醇血管舒张作用涉及L型钙通道抑制。
Adv Pharmacol Sci. 2010;2010:534184. doi: 10.1155/2010/534184. Epub 2010 Mar 30.
3
Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event.瑞舒伐他汀（10毫克）与阿托伐他汀（40毫克）对既往有动脉粥样硬化事件的白种男性Rho激酶活性影响的比较。
Am J Cardiol. 2009 Feb 15;103(4):437-41. doi: 10.1016/j.amjcard.2008.10.008. Epub 2008 Dec 25.
4
Antiatherosclerotic effects of statins: LDL versus non-LDL effects.他汀类药物的抗动脉粥样硬化作用：低密度脂蛋白与非低密度脂蛋白的作用
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本文引用的文献

1
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft.胆固醇使血管平滑肌致敏，以诱导由鞘氨醇磷酸胆碱- Rho激酶途径介导的Ca2+敏感性增加：膜筏的可能作用。
Circ Res. 2006 Aug 4;99(3):299-306. doi: 10.1161/01.RES.0000235877.33682.e9. Epub 2006 Jul 6.
2
Physiological role of ROCKs in the cardiovascular system.ROCKs在心血管系统中的生理作用。
Am J Physiol Cell Physiol. 2006 Mar;290(3):C661-8. doi: 10.1152/ajpcell.00459.2005.
3
Rho GTPases, statins, and nitric oxide.Rho鸟苷三磷酸酶、他汀类药物与一氧化氮
Circ Res. 2005 Dec 9;97(12):1232-5. doi: 10.1161/01.RES.0000196564.18314.23.
4
Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA).血压及其他变量在盎格鲁-斯堪的纳维亚心脏结局试验-降压组（ASCOT-BPLA）中所观察到的心血管事件发生率差异中的作用。
Lancet. 2005;366(9489):907-13. doi: 10.1016/S0140-6736(05)67186-3.
5
Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.抑制Rho激酶（ROCK）可增加脑血流量并起到中风保护作用。
Stroke. 2005 Oct;36(10):2251-7. doi: 10.1161/01.STR.0000181077.84981.11. Epub 2005 Sep 1.
6
Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice.Rho相关蛋白激酶促进小鼠早期动脉粥样硬化病变形成。
Circ Res. 2003 Oct 31;93(9):884-8. doi: 10.1161/01.RES.0000099062.55042.9A. Epub 2003 Oct 2.
7
Rocks: multifunctional kinases in cell behaviour.ROCKs：细胞行为中的多功能激酶
Nat Rev Mol Cell Biol. 2003 Jun;4(6):446-56. doi: 10.1038/nrm1128.
8
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.在盎格鲁-斯堪的纳维亚心脏结局试验——降脂分支（ASCOT-LLA）中，阿托伐他汀对胆固醇浓度处于平均水平或低于平均水平的高血压患者冠心病和中风事件的预防作用：一项多中心随机对照试验。
Lancet. 2003 Apr 5;361(9364):1149-58. doi: 10.1016/S0140-6736(03)12948-0.
9
Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.Rho激酶抑制剂法舒地尔对变异性心绞痛患者冠状动脉痉挛的抑制作用
Circulation. 2002 Apr 2;105(13):1545-7. doi: 10.1161/hc1002.105938.
10
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.Rho激酶可能参与人类高血压的发病机制。
Hypertension. 2001 Dec 1;38(6):1307-10. doi: 10.1161/hy1201.096541.

Rho-kinase: a potential link between hypercholesterolemia and abnormal vascular smooth muscle contraction.

作者信息

Liao James K

出版信息

Circ Res. 2006 Aug 4;99(3):238-9. doi: 10.1161/01.RES.0000236798.01988.5d.

DOI:10.1161/01.RES.0000236798.01988.5d
PMID:16888249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2662040/
Abstract
摘要