Oki Izumi, Nakamura Yosikazu, Okamura Tomonori, Okayama Akira, Hayakawa Takehito, Kita Yoshikuni, Ueshima Hirotsugu
Department of Public Health, Jichi Medical University, Tochigi, Japan.
Cerebrovasc Dis. 2006;22(5-6):409-15. doi: 10.1159/000094860. Epub 2006 Aug 4.
The relationship between body mass index (BMI) and stroke mortality remains unclear. The aim of the present study was to elucidate the relationship between BMI and stroke death in a representative cohort of Japanese men and women.
We analyzed a database of 9,526 men and women aged 30 years and older who were randomly selected throughout Japan in 1980. These individuals had no history of stroke and were followed for 19 years. Hazard ratios (HR) and their 95% confidence intervals (CI) of deaths due to total stroke, cerebral infarction, and intracerebral hemorrhage were examined using Cox's proportional hazards regression models of BMI levels.
A U-shaped association between BMI and cerebral infarction mortality was observed. Participants with the highest BMI category (BMI > or = 30.0) showed a significantly highest HR for cerebral infarction (HR 2.46, 95% CI 1.01-5.99). The excess risk at the lower extreme of the BMI was confined to men. These associations did not change after excluding deaths occurring in the first 2 years of follow-up.
In the Japanese general population, a U-shaped association between BMI and cerebral infarction mortality was found and the excess risk at the lower extreme of the BMI was confined to men.
体重指数（BMI）与卒中死亡率之间的关系仍不明确。本研究的目的是阐明在具有代表性的日本男性和女性队列中，BMI与卒中死亡之间的关系。
我们分析了1980年在日本全国随机选取的9526名30岁及以上男性和女性的数据库。这些个体无卒中病史，随访19年。使用BMI水平的Cox比例风险回归模型，研究总卒中、脑梗死和脑出血所致死亡的风险比（HR）及其95%置信区间（CI）。
观察到BMI与脑梗死死亡率之间呈U形关联。BMI最高类别（BMI≥30.0）的参与者脑梗死的HR显著最高（HR 2.46，95%CI 1.01 - 5.99）。BMI下限的额外风险仅限于男性。排除随访前2年发生的死亡后，这些关联未改变。
在日本普通人群中，发现BMI与脑梗死死亡率之间呈U形关联，且BMI下限的额外风险仅限于男性。
