Ubol S, Hemachudha T, Whitaker J N, Griffin D E
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore.
J Neuroimmunol. 1990 Feb;26(2):107-11. doi: 10.1016/0165-5728(90)90081-w.
Development of neurologic complications after Semple rabies vaccine is closely linked to development of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassay in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89 and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic complication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 45-170.
森普尔狂犬病疫苗接种后神经并发症的发生与抗髓磷脂碱性蛋白（MBP）抗体的产生密切相关。采用酶免疫分析法对27例疫苗接种后出现并发症患者的血清和脑脊液中抗体所针对的MBP片段进行了分析。大多数抗体针对的是MBP肽段45 - 89和90 - 170区域。针对MBP肽段1 - 44、45 - 89和90 - 170的抗体特异性与疫苗接种后神经并发症的类型之间无明显相关性。我们得出结论，人类B淋巴细胞中针对人MBP产生反应的免疫球蛋白库倾向于MBP分子中包含45 - 170位氨基酸残基的部分。
