Hemachudha T, Phanuphak P, Johnson R T, Griffin D E, Ratanavongsiri J, Siriprasomsup W
Neurology. 1987 Apr;37(4):550-6. doi: 10.1212/wnl.37.4.550.
We studied 61 patients with complications of Semple-type postexposure rabies immunization. Thirty-six had neurologic signs, and 25 had only fever, headache, or myalgia. Thirty-two patients had CNS complications, and 4 had an acute peripheral neuropathy. Disease was acute and monophasic in 33, but 3 patients had progressive disease, including 1 patient with a relapsing-remitting course. No clinical features, including CSF content of myelin basic protein, were prognostic indicators. In three of six patients with encephalomyelitis, lymphocytes showed a proliferative response to myelin.
我们研究了61例接种Semple型暴露后狂犬病疫苗出现并发症的患者。36例有神经系统症状，25例仅有发热、头痛或肌痛。32例有中枢神经系统并发症，4例有急性周围神经病变。33例患者病情呈急性单相性，但3例患者病情呈进行性发展，其中1例呈复发-缓解病程。包括髓鞘碱性蛋白的脑脊液含量在内，没有任何临床特征可作为预后指标。在6例脑脊髓炎患者中的3例，淋巴细胞对髓鞘有增殖反应。
