偕二氟亚甲基化大豆苷元类似物的合成及其对U2OS细胞周期的抑制作用。
Synthesis of gem-difluoromethylenated daidzein analogues and their inhibitory effect on U2OS cell cycle.
作者信息
Meng Wei-Dong, Zhang Zhi-Hang, Qing Feng-Ling, Li Qing, Zhang Yue-Yue, Wang Hui-Sheng
机构信息
College of Chemistry and Chemical Engineering, Donghua University, 2999 Remin Rd. North, Songjiang District, Shanghai 201620, China.
出版信息
Pharmazie. 2006 Jul;61(7):648-9.
gem-Difluoromethylenated daidzein analogues 2 and 4 were obtained by the insertion reaction of difluorocarbene. A series of alkylated fluorine-containing daidzein analogues 3a-f and 5a-f were synthesized. All the compounds were tested for the inhibitory effect on U2OS cell cycle in vitro. The results showed that 7-octyloxy-3-(4-difluoromethoxyphenyl)-chromen-4-one 5d was the most active inhibitor.
偕二氟亚甲基化大豆苷元类似物2和4通过二氟卡宾的插入反应获得。合成了一系列烷基化含氟大豆苷元类似物3a-f和5a-f。对所有化合物进行了体外对U2OS细胞周期抑制作用的测试。结果表明，7-辛氧基-3-(4-二氟甲氧基苯基)-色原酮-4-酮5d是最具活性的抑制剂。
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