Glaziovianin A 对 HeLa S3 细胞周期进程和纺锤体形成的构效关系研究。
Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
机构信息
Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.
出版信息
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5402-4. doi: 10.1016/j.bmcl.2010.07.111. Epub 2010 Aug 1.
PMID:20719506
Abstract
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.
摘要
合成了抗肿瘤异黄酮 glaziovianin A 的各种衍生物，并研究了它们对 HeLa S3 细胞的细胞毒性。与 glaziovianin A 相比，O7-烯丙基衍生物对 HeLa S3 细胞的细胞毒性更强，是一种更强效的 M 期抑制剂。
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