Gonzalo-Garijo M A, Bobadilla P
Allergology Department, Infanta Cristina University Hospital, Badajoz, Spain.
J Investig Allergol Clin Immunol. 2006;16(4):266-7.
A 68-year-old woman with a medical history significant for Sjögren syndrome and leukocytoclastic vasculitis of small vessels presented to the emergency department with chills, malaise, a temperature of 39 degrees C, nausea, vomiting, and hypotension. Fifteen minutes earlier she had taken ibuprofen for flu-like symptoms. She was treated with a perfusion of intravenous saline, paracetamol, and ciprofloxacin with improvement 24 hours later. Three months later, she had a similar episode, without hypotension. An oral challenge test with ibuprofen in the hospital produced the same symptoms 3 hours after the last dose. She was treated with metamizole and paracetamol and was asymptomatic the next day. This is the first report of a febrile reaction to ibuprofen in a patient with Sjogren's syndrome.
一名68岁女性，有干燥综合征和小血管白细胞破碎性血管炎病史，因寒战、不适、体温39摄氏度、恶心、呕吐和低血压就诊于急诊科。15分钟前她因流感样症状服用了布洛芬。她接受了静脉生理盐水灌注、对乙酰氨基酚和环丙沙星治疗，24小时后症状改善。三个月后，她出现了类似发作，但没有低血压。在医院进行的布洛芬口服激发试验在最后一剂后3小时出现了相同症状。她接受了安乃近和对乙酰氨基酚治疗，第二天无症状。这是干燥综合征患者对布洛芬发生发热反应的首例报告。
