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以色列(北纬32.6度)针对季节性情感障碍的强光疗法:一项单病例安慰剂对照研究。

Bright light therapy for seasonal affective disorder in Israel (latitude 32.6 degrees N): a single case placebo-controlled study.

作者信息

Moscovici L

机构信息

Department of Psychiatry, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Acta Psychiatr Scand. 2006 Sep;114(3):216-8; discussion 218-9. doi: 10.1111/j.1600-0447.2006.00844.x.

Abstract

INTRODUCTION

We describe a patient diagnosed as having seasonal affective disorder (SAD, winter depression), an unlikely condition in Israel (latitude 32.6 degrees N), a country with relatively minor daylight photoperiodic changes between seasons.

METHOD

Case report.

RESULTS

A 46-year-old woman with a clinical picture of depression (Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria for 'major depression with seasonal pattern') reacted positively to 3 weeks of daily bright light therapy of 10,000 lux/wide spectrum. She was asked to wear dark sunglasses during placebo sessions to accommodate an A-B-C single-case-design. The intervention resulted in an improvement of 74-80% in the Hamilton anxiety and depression scales (clinician-rated) and the Beck depression inventory, similar to results obtained in high latitude regions. The depression and anxiety levels returned close to baseline levels following 1 week of the placebo intervention.

CONCLUSION

Seasonal affective disorder is apparently not limited to certain latitudes. The effect of light therapy was short-lived after discontinuation of the treatment, with rapid relapse occurring in the placebo phase.

摘要

引言

我们描述了一名被诊断为患有季节性情感障碍(SAD,冬季抑郁症)的患者,在以色列(北纬32.6度)这种情况不太常见,该国不同季节之间的日光光周期变化相对较小。

方法

病例报告。

结果

一名46岁女性,具有抑郁症的临床表现(符合《精神疾病诊断与统计手册》中“季节性模式的重度抑郁症”的诊断标准),对为期3周、每天10000勒克斯/广谱的强光疗法反应良好。在安慰剂治疗期间,要求她佩戴深色太阳镜,以适应A - B - C单病例设计。干预使汉密尔顿焦虑和抑郁量表(临床医生评定)以及贝克抑郁量表的得分改善了74% - 80%,与在高纬度地区获得的结果相似。在安慰剂干预1周后,抑郁和焦虑水平恢复到接近基线水平。

结论

季节性情感障碍显然并不局限于某些纬度。停止治疗后,光疗法的效果是短暂的,在安慰剂阶段迅速复发。

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