Labbate L A, Lafer B, Thibault A, Rosenbaum J F, Sachs G S
Department of Psychiatry, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Biol Psychiatry. 1995 Dec 1;38(11):747-50. doi: 10.1016/0006-3223(95)00069-0.
Most previous phototherapy research has been conducted on trials of 1 week duration. This study compares response to phototherapy at weeks 1 and 2. All subjects (n = 26) were between 18 and 65 years and met Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, revised, (DSM III-R) criteria for major depression, recurrent, seasonal pattern and had a Hamilton Depression Rating Scale score (HAM-D) > or = 20. A rater blinded to treatment schedule and study hypothesis repeated the HAM-D-31 1 and 2 weeks after baseline to assess treatment response to bright light. Response rates at week 1 defined by 50% reduction in HAM-D-31 and HAM-D-31 score < 8 were 62% and 27%, respectively. At week 2, however, 65% had a 50% reduction in HAM-D-31 and 62% had a HAM-D-31 < score 8 (chi-square = 6, p = 0.01). Four patients (15%) who were nonresponders at week 1 responded after 2 weeks. The results show a statistically different outcome after 2 weeks of treatment and suggest the necessity of longer trials of phototherapy.
以往大多数光疗研究都是为期1周的试验。本研究比较了第1周和第2周光疗的反应。所有受试者（n = 26）年龄在18至65岁之间，符合《精神疾病诊断与统计手册》第3版修订版（DSM III-R）中复发性季节性重度抑郁症的标准，且汉密尔顿抑郁量表评分（HAM-D）≥20。一名对治疗方案和研究假设不知情的评估者在基线后1周和2周重复进行HAM-D-31评估，以评估对强光治疗的反应。以HAM-D-31降低50%且HAM-D-31评分<8定义的第1周反应率分别为62%和27%。然而，在第2周，65%的患者HAM-D-31降低了50%，62%的患者HAM-D-31评分<8（卡方=6，p = 0.01）。4名在第1周无反应的患者（15%）在2周后有反应。结果显示治疗2周后有统计学差异的结果，并表明有必要进行更长时间的光疗试验。
