XPD基因多态性与慢性苯中毒易感性的关系
[Association between polymorphisms of XPD gene and susceptibility to chronic benzene poisoning].
作者信息
Huang Hui-long, Xu Jian-ning, Wang Quan-kai, Wang Ya-wen, Yang Min, Chen Yan, Li Gui-lan
机构信息
Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
出版信息
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jul;24(7):390-3.
OBJECTIVE
To explore the relationship between genetic polymorphisms of XPD gene and susceptibility to chronic benzene poisoning.
METHODS
A case control study was conducted. Eighty patients diagnosed with chronic benzene poisoning and 62 workers occupationally exposed to benzene who were engaged in the same working time and job title as patients were investigated. PCR-RFLP was used for detecting the single nucleotide polymorphisms (SNPs) on codon156, codon312 and codon751 of XPD gene.
RESULTS
There was a 2.903 times (95% CI: 1.054 - 7.959, P = 0.039 2) increased risk of chronic benzene poisoning in the subjects carrying XPD 751Gln variant allele compared with those carrying XPD 751Lys/Lys genotype, after adjusted for sex, length of service, smoking and drinking status.
CONCLUSION
The subjects with XPD 751Gln variant allele are more susceptive to benzene.
目的
探讨XPD基因多态性与慢性苯中毒易感性的关系。
方法
进行病例对照研究。调查了80例诊断为慢性苯中毒的患者和62名与患者工作时间和职称相同的职业性接触苯的工人。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测XPD基因第156密码子、第312密码子和第751密码子的单核苷酸多态性（SNP）。
结果
校正性别、工龄、吸烟和饮酒状况后，携带XPD 751Gln变异等位基因的受试者患慢性苯中毒的风险是携带XPD 751Lys/Lys基因型受试者的2.903倍（95%可信区间：1.054 - 7.959，P = 0.039 2）。
结论
携带XPD 751Gln变异等位基因的受试者对苯更易感。
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