Stenvinkel Peter
Division of renal medicine K56, department of clinical science, Karolinska Institutet, Karolinska University Hospital at Huddinge, 14186 Stockholm, Suède.
Nephrol Ther. 2006 Jul;2(3):111-9. doi: 10.1016/j.nephro.2006.04.004. Epub 2006 May 19.
Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in chronic kidney disease (CKD). As traditional risk factors cannot alone explain the unacceptable high prevalence and incidence of CVD in this population, inflammation (which is interrelated to insulin resistance, oxidative stress, wasting and endothelial dysfunction) has been suggested to be a significant contributor. Indeed, several different inflammatory biomarkers, such as high sensitivity C-reactive protein (CRP) has been shown to independently predict mortality in CKD patients. The causes of the highly prevalent state of inflammation in CKD are multiple and include factors such as volume overload, co-morbidity, intercurrent clinical events, the dialysis procedure per se as well as genetic factors. Indeed, multiple cytokine DNA polymorphisms may affect the inflammatory state, the clinical phenotype as well as outcome in this patient population.
心血管疾病（CVD）仍然是慢性肾脏病（CKD）发病和死亡的主要原因。由于传统风险因素无法单独解释该人群中CVD令人难以接受的高患病率和发病率，炎症（与胰岛素抵抗、氧化应激、消瘦和内皮功能障碍相关）被认为是一个重要因素。事实上，几种不同的炎症生物标志物，如高敏C反应蛋白（CRP）已被证明可独立预测CKD患者的死亡率。CKD中炎症高度普遍的原因是多方面的，包括容量超负荷、合并症、并发临床事件、透析程序本身以及遗传因素。的确，多种细胞因子DNA多态性可能影响该患者群体的炎症状态、临床表型以及预后。
