HLA 类 I 和 II 等位基因对韩国儿童免疫预防后围产期乙型肝炎病毒感染影响的改变。

Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children.

机构信息

Department of Pediatrics, St. Vincent's Hospital, The Catholic University of Korea, 93 Ji-dong, Paldal-gu, Suwon, Kyonggi-do 442-060, Republic of Korea.

出版信息

Hepatol Res. 2006 Jun;35(2):118-26. doi: 10.1016/j.hepres.2006.03.004.

DOI:10.1016/j.hepres.2006.03.004

PMID:16890179

Abstract

Some HLA alleles are known to be associated with hepatitis B virus (HBV) persistence. In order to find out the relationship between HLA and perinatal HBV infection after prophylaxis, we typed HLA classes I and II in 38 HBeAg-positive mothers, their children (19 succeeded and 19 failed in prophylaxis) and 198 HBsAg-negative healthy controls. HLA-B35 (RR=2.8, p<0.03), Cw07 (RR=2.7, p<0.02), DRB107 (RR=3.6, p<0.006), DQA102 (RR=3.6, p<0.02) and DQB102 (RR=2.4, p<0.05) alleles were higher and DRB113 (RR=0.3, p<0.03) and DPB10401 (RR=0.1, p<0.01) alleles were lower frequencies in HBeAg-positive mothers than in the control. In failed children to the perinatal HBV prophylaxis, HLA-Cw0303 allele was significantly higher (p<0.05) and DPB10202 allele was lower (p<0.03) than in succeeded children. These results suggest the influences of certain HLA alleles on naturally acquired chronic HBV infection may be changed by perinatal HBV prophylaxis.

摘要

一些 HLA 等位基因与乙型肝炎病毒 (HBV) 持续感染有关。为了探讨预防后围生期 HBV 感染与 HLA 的关系，我们对 38 例 HBeAg 阳性母亲、其子女（预防成功 19 例，预防失败 19 例）和 198 例 HBsAg 阴性健康对照者进行了 HLA Ⅰ类和Ⅱ类基因分型。HLA-B35（RR=2.8，p<0.03）、Cw07（RR=2.7，p<0.02）、DRB107（RR=3.6，p<0.006）、DQA102（RR=3.6，p<0.02）和 DQB102（RR=2.4，p<0.05）等位基因频率在 HBeAg 阳性母亲中较高，而 DRB113（RR=0.3，p<0.03）和 DPB10401（RR=0.1，p<0.01）等位基因频率较低。在预防失败的儿童中，HLA-Cw0303 等位基因明显升高（p<0.05），DPB10202 等位基因明显降低（p<0.03）。这些结果提示，某些 HLA 等位基因对自然获得性慢性 HBV 感染的影响可能因围生期 HBV 预防而改变。