Donati Chiara, Bruni Paola
Dipartimento di Scienze Biochimiche, Istituto Interuniversitario di Miologia (IIM), Università degli Studi di Firenze, Viale G.B. Morgagni 50, 50134 Firenze, Italy.
Biochim Biophys Acta. 2006 Dec;1758(12):2037-48. doi: 10.1016/j.bbamem.2006.06.015. Epub 2006 Jun 27.
The bioactive sphingolipid sphingosine 1-phosphate (S1P) elicits robust cytoskeletal rearrangement in a large variety of cell systems, mainly acting through a panel of specific cell surface receptors, named S1P receptors. Recent studies have begun to delineate the molecular mechanisms involved in the complex process responsible for cytoskeletal rearrangement following S1P ligation to its receptors. Notably, changes of cell shape and/or motility induced by S1P via cytoskeletal remodelling are functional to the biological action exerted by S1P which appears to be highly cell-specific. This review focuses on the current knowledge of the regulatory mechanisms of cytoskeleton dynamics elicited by S1P, with special emphasis on the relationship between cytoskeletal remodelling and the biological effects evoked by the sphingolipid in various cell types.
生物活性鞘脂类物质1-磷酸鞘氨醇（S1P）在多种细胞系统中引发强烈的细胞骨架重排，主要通过一组特定的细胞表面受体（称为S1P受体）发挥作用。最近的研究已开始阐明S1P与其受体结合后，在负责细胞骨架重排的复杂过程中所涉及的分子机制。值得注意的是，S1P通过细胞骨架重塑诱导的细胞形状和/或运动性变化，对于S1P所发挥的生物学作用具有功能性意义，而这似乎具有高度的细胞特异性。本综述聚焦于目前关于S1P引发的细胞骨架动力学调节机制的知识，特别强调细胞骨架重塑与该鞘脂类物质在各种细胞类型中所引发的生物学效应之间的关系。
