1-磷酸鞘氨醇在平滑肌收缩中的作用。
The role of sphingosine-1-phosphate in smooth muscle contraction.
作者信息
Watterson Kenneth R, Ratz Paul H, Spiegel Sarah
机构信息
Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall Street, P.O. Box 980614, Sanger Hall, Room 2-011, Richmond, VA 23298-0614, USA.
出版信息
Cell Signal. 2005 Mar;17(3):289-98. doi: 10.1016/j.cellsig.2004.09.013.
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that is known to mediate diverse cellular responses including cell growth, survival, and migration. Most of these effects have been attributed to its binding to a specific subfamily of G protein-coupled receptors (GPCR), namely S1P(1-5). Recent studies have suggested that S1P also plays a prominent role in the contraction of various types of smooth muscle. This review provides a brief overview of its role in this process and also highlights how S1P-dependent signaling serves as an important regulator of smooth muscle contraction.
1-磷酸鞘氨醇（S1P）是一种生物活性鞘脂代谢物，已知其介导多种细胞反应，包括细胞生长、存活和迁移。这些作用大多归因于它与G蛋白偶联受体（GPCR）的一个特定亚家族，即S1P(1-5)的结合。最近的研究表明，S1P在各种类型平滑肌的收缩中也起着重要作用。本文综述简要概述了其在这一过程中的作用，并强调了S1P依赖性信号传导如何作为平滑肌收缩的重要调节因子。
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