Loginova Natalia V, Koval'chuk Tat'yana V, Zheldakova Rimma A, Osipovich Nikolai P, Sorokin Victor L, Polozov Genrikh I, Ksendzova Galina A, Glushonok Gennady K, Chernyavskaya Anna A, Shadyro Oleg I
Faculty of Chemistry, Belarusian State University, Leningradskaya str. 14, 220050 Minsk, Belarus.
Bioorg Med Chem Lett. 2006 Oct 15;16(20):5403-7. doi: 10.1016/j.bmcl.2006.07.065. Epub 2006 Aug 4.
Cu(II) complexes with 4,6-di(tert-butyl)-2-aminophenol (I) and 2-anilino-4,6-di(tert-butyl)phenol (II) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, UV-vis, ESR, and conductance measurements. The compounds I and II can coordinate in their singly deprotonated forms and behave as bidentate O,N-coordinated ligands; their CuL(2) complexes are characterized by CuN(2)O(2) coordination modes and square planar geometry. In vitro antimicrobial screening against Gram-positive and Gram-negative bacteria, yeasts, and moulds indicated that the compound I and its Cu(II) complex were more active than Questiomycin B, the compound II, and its Cu(II) complex.
已合成了铜（II）与4,6-二（叔丁基）-2-氨基苯酚（I）和2-苯胺基-4,6-二（叔丁基）苯酚（II）的配合物，并通过元素分析、热重/差示热分析（TG/DTA）、傅里叶变换红外光谱（FT-IR）、紫外可见光谱（UV-vis）、电子顺磁共振（ESR）和电导率测量对其进行了表征。化合物I和II可以以单去质子化形式配位，并表现为双齿O，N配位配体；它们的CuL(2)配合物具有CuN(2)O(2)配位模式和平面正方形几何结构。针对革兰氏阳性菌和革兰氏阴性菌、酵母和霉菌的体外抗菌筛选表明，化合物I及其铜（II）配合物比喹西霉素B、化合物II及其铜（II）配合物更具活性。
