希夫碱 Cu(II)、Ni(II)和 Co(II)配合物的合成、光谱表征及抗菌评价。
Synthesis, spectral characterization and antimicrobial evaluation of Schiff base Cu (II), Ni (II) and Co (II) complexes.
机构信息
Department of Chemistry, Vardhaman College, Bijnor 246701, Uttar Pradesh, India.
出版信息
Eur J Med Chem. 2010 Jul;45(7):3056-62. doi: 10.1016/j.ejmech.2010.03.036. Epub 2010 Mar 29.
M(II) complexes of the type [HLCu(2)Cl(3)], [HLCu(2)(O(CO)CH(3))(3)], [HLM(2)Cl(4)(H(2)O)(3)] and [HLM(2)(OC(O)CH(3))(4)(H(2)O)(3)], where M=Ni(II), Co(II) have been synthesized by condensation of 3-acyl-2-one indol and hydrazinecarbothioamide (2:1) in the presence of divalent metal salt in methanolic medium. The complexes have been characterized with the help of elemental analysis, conductance measurements, magnetic measurements and their structural configuration have been determined by various spectroscopic (electronic, IR, (1)H NMR, (13)C NMR, GCMS) techniques. Electronic and magnetic moments of the complexes indicate that the geometries of the metal centers are either distorted octahedral, or square planer. These metal complexes were also tested for their antibacterial and antifungal activities to assess their inhibiting potential.
标题
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[HLCu(2)Cl(3)]、[HLCu(2)(O(CO)CH(3))(3)]、[HLM(2)Cl(4)(H(2)O)(3)] 和 [HLM(2)(OC(O)CH(3))(4)(H(2)O)(3)] 型 M(II) 配合物的合成方法如下：在甲醇介质中，将 3-酰基-2-酮吲哚和缩二氨硫脲（2:1）与二价金属盐缩合，得到配合物。通过元素分析、电导测量、磁性测量以及各种光谱（电子、IR、(1)H NMR、(13)C NMR、GCMS）技术对配合物进行了表征。配合物的电子和磁矩表明，金属中心的几何形状为扭曲的八面体或平面正方形。这些金属配合物还进行了抗菌和抗真菌活性测试，以评估它们的抑制潜力。
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