Papadopoulos Kyriakos
Institute for Drug Development, Cancer Therapy and Research Center, and Division of Medical Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, TX, USA.
Semin Oncol. 2006 Aug;33(4):449-56. doi: 10.1053/j.seminoncol.2006.04.008.
The targeting of anti-apoptotic members of the Bcl-2 family of proteins, especially Bcl-2, is the focus of efforts to modulate the intrinsic pathway of apoptosis and effect tumor death. Current understanding of the role of Bcl-2 family proteins and strategies and recent developments in drug inhibitors of these proteins, particularly antisense oligonucleotides and targeted small molecules, are reviewed.
靶向Bcl-2蛋白家族的抗凋亡成员，尤其是Bcl-2，是调节细胞凋亡内在途径并实现肿瘤细胞死亡研究工作的重点。本文综述了目前对Bcl-2家族蛋白作用的理解、针对这些蛋白的策略以及药物抑制剂（特别是反义寡核苷酸和靶向小分子）的最新进展。
