Nowling Tamara K, Gilkeson Gary S
Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas Street, Ste 912 CSB, Charleston, SC 29425, United States.
Autoimmun Rev. 2006 Jul;5(6):377-82. doi: 10.1016/j.autrev.2005.10.005. Epub 2005 Dec 13.
Ets transcription factors function throughout development in such varied processes as cellular proliferation, apoptosis, differentiation and migration. Many have been implicated to play important roles in hematopoiesis, vasculogenesis/angiogenesis and myogenesis. Fli1 is an Ets family member that is essential for development and increasing evidence suggests modulating Fli1 gene expression impacts lymphocyte function and is important in the autoimmune disease lupus. Presently, it is unknown how Fli1 gene expression is controlled in lymphocytes. Identifying upstream regulators of Fli1 in lymphocytes will be critical for understanding lymphocyte development and the consequences of dysregulation and may be of value in developing future treatments for lupus.
Ets转录因子在整个发育过程中发挥作用，涉及细胞增殖、凋亡、分化和迁移等多种不同过程。许多Ets转录因子已被证实参与造血、血管生成/血管新生以及肌生成等重要过程。Fli1是Ets家族成员之一，对发育至关重要，越来越多的证据表明，调节Fli1基因表达会影响淋巴细胞功能，且在自身免疫性疾病狼疮中具有重要作用。目前，尚不清楚Fli1基因在淋巴细胞中是如何被调控的。确定淋巴细胞中Fli1的上游调节因子对于理解淋巴细胞发育以及失调的后果至关重要，可能对开发未来狼疮治疗方法具有重要价值。
