Xu Wang-Dong, Zhang Min, Zhao Yi, Liu Yi
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan, 610041, People's Republic of China.
Suzhou National High-tech District Center for Disease Prevention and Control, 35 Dengwei Road, Suzhou, Jiangsu, 215011, People's Republic of China.
Inflammation. 2016 Feb;39(1):493-498. doi: 10.1007/s10753-015-0257-3.
Systemic lupus erythematosus (SLE) is an autoimmune disease. The friend leukemia insertion site 1 (Fli-1) belongs to the Ets family of transcription factors. Recent findings suggested that expression of Fli-1 was abnormal in SLE patients and lupus mice. In addition, functional analysis indicated that Fli-1 plays a key role in the development of this complex autoimmune disorder. Here, we review the updated evidence indicating the roles of Fli-1 in autoimmune lupus. Hopefully, the information obtained may result in a better understanding of the pathogenesis of the systemic autoimmune disease.
系统性红斑狼疮（SLE）是一种自身免疫性疾病。Friend白血病插入位点1（Fli-1）属于转录因子的Ets家族。最近的研究结果表明，SLE患者和狼疮小鼠中Fli-1的表达异常。此外，功能分析表明，Fli-1在这种复杂的自身免疫性疾病的发展中起关键作用。在此，我们综述了表明Fli-1在自身免疫性狼疮中作用的最新证据。希望所获得的信息能有助于更好地理解这种系统性自身免疫性疾病的发病机制。
