Llobet Juan M, Falcó Gemma, Bocio Ana, Domingo José L
Toxicology Unit, School of Pharmacy, University of Barcelona, Avgda. Diagonal, 08028 Barcelona, Spain.
Chemosphere. 2007 Jan;66(6):1107-13. doi: 10.1016/j.chemosphere.2006.06.058. Epub 2006 Aug 7.
The concentrations of polychlorinated naphthalenes (PCNs) were determined in samples of 14 edible marine species (sardine, tuna, anchovy, mackerel, swordfish, salmon, hake, red mullet, sole, cuttlefish, squid, clam, mussel and shrimp), which are widely consumed by the population of Catalonia, Spain. The daily intake of PCNs associated with this consumption was also determined. A total of 42 composite samples were analyzed by HRGC/HRMS. The highest PCN levels (ng/kg of fresh weight) were found in salmon (227) followed by mackerel (95) and red mullet (68), while the lowest levels of total PCNs corresponded to shrimp (4.9) and cuttlefish (2.7). With the exception of cephalopods and shellfish species, in which tetra-CN was the predominant homologue, penta-CN (60%) was the predominant contributor to total PCNs. For a standard male adult, PCN intake through the consumption of edible marine species was 1.53 ng/day. The highest contributions to this intake (ng/day) corresponded to salmon (0.41), sole (0.28) and tuna (0.24). Concerning health risks, species-specific TEFs such as those reported by WHO and NATO for PCDD/Fs and dioxin-like PCBs are not currently available for PCN congeners. Although in general terms the results of the present study do not seem to suggest specific risks derived from exposure to PCNs through fish and seafood consumption, to establish the contribution of individual PCN congeners to total TEQ is clearly necessary for the assessment of human health risks.
对14种可食用海洋物种（沙丁鱼、金枪鱼、凤尾鱼、鲭鱼、箭鱼、三文鱼、无须鳕、红鲻鱼、鳎鱼、乌贼、鱿鱼、蛤蜊、贻贝和虾）的样本进行了多氯萘（PCNs）浓度测定，这些物种在西班牙加泰罗尼亚地区被人们广泛食用。还测定了与这种食用相关的PCNs每日摄入量。通过高分辨率气相色谱/高分辨率质谱法对总共42个混合样本进行了分析。PCN含量最高（纳克/千克鲜重）的是三文鱼（227），其次是鲭鱼（95）和红鲻鱼（68），而PCNs总量最低的是虾（4.9）和乌贼（2.7）。除头足类和贝类物种外，四氯萘是主要同系物，五氯萘（60%）是PCNs总量的主要贡献者。对于标准成年男性，通过食用可食用海洋物种摄入的PCN为1.53纳克/天。对该摄入量贡献最大的（纳克/天）是三文鱼（0.41）、鳎鱼（0.28）和金枪鱼（0.24）。关于健康风险，目前尚无针对PCN同系物的特定物种毒性当量因子，如世界卫生组织和北约报告的二噁英/呋喃类多氯联苯和类二噁英多氯联苯的毒性当量因子。虽然总体而言，本研究结果似乎并未表明通过食用鱼类和海鲜接触PCNs会带来特定风险，但明确确定单个PCN同系物对总毒性当量的贡献对于评估人类健康风险显然是必要的。
