Daehnfeldt J L, Schülein M
Br J Cancer. 1975 Apr;31(4):424-8. doi: 10.1038/bjc.1975.81.
The determination of hormone inducible proteins in endocrine tumours may yield information about the presence of hormone dependent tumour cells. We have estimated the high affinity oestradiol binding capacity in primary mammary carcinomata of 57 postmenopausal patients. Glucose-6-phosphate dehydrogenase and lactose synthetase are known from animal experiments to be hormone inducible. Therefore, in biopsies of sufficient size the activity of glucose-6-phosphate dehydrogenase (47 pateints) and lactose synthetase (23 patients) was also studied. It was found that biopsies with high binding capacity also showed high activities of glucose-6-phosphate dehydrogenase and lactose synthetase A protein (galactosyl transferase). No lactose synthetase B protein (alpha-lactalbumin) has been discovered in the tumours. The present observations may be considered suggestive evidence of a relationship between high oestradiol binding capcity and high activities of the two enzymes on the one hand and hormone dependence of the tumour on the other. However, further clinical studies are required before final conclusions in this respect can be drawn.
测定内分泌肿瘤中激素诱导蛋白可能会得出有关激素依赖性肿瘤细胞存在的信息。我们已经估算了57名绝经后患者原发性乳腺癌中高亲和力雌二醇结合能力。从动物实验得知，葡萄糖-6-磷酸脱氢酶和乳糖合成酶是激素可诱导的。因此，对于足够大小的活检样本，我们还研究了葡萄糖-6-磷酸脱氢酶（47例患者）和乳糖合成酶（23例患者）的活性。结果发现，具有高结合能力的活检样本中葡萄糖-6-磷酸脱氢酶和乳糖合成酶A蛋白（半乳糖基转移酶）的活性也很高。在肿瘤中未发现乳糖合成酶B蛋白（α-乳白蛋白）。目前的观察结果可以被视为一方面高雌二醇结合能力与这两种酶的高活性之间存在关系，另一方面肿瘤具有激素依赖性的提示性证据。然而，在就此得出最终结论之前，还需要进一步的临床研究。
