Duffy M J, Duffy G J
Clin Chim Acta. 1977 Jan 17;74(2):167-71. doi: 10.1016/0009-8981(77)90218-2.
Estradiol receptors and glucose-6-phosphate dehydrogenase, an enzyme induced by estrogens, were measured in both benign and malignant human breast tumors. The mean glucose-6-phosphate dehydrogenase activity was higher in the malignant tumors than in the benign tumors. Tumors containing estradiol receptors contained higher activities of glucose-6-phosphate dehydrogenase than tumors without receptors. In breast carcinomas with and without estradiol receptors glucose-6-phosphate dehydrogenase gave 3 isoenzymes with very similar electrophoretic pattern after polyacrylamide gel electrophoresis. The results showed that although glucose-6-phosphate dehydrogenase was higher in estradiol receptor positive than in estradiol receptor negative tumors there was no significant correlation between the estradiol receptor concentration and glucose-6-phosphate dehydrogenase activity in human breast tumors.
在良性和恶性人类乳腺肿瘤中均检测了雌二醇受体以及雌激素诱导产生的一种酶——葡萄糖-6-磷酸脱氢酶。恶性肿瘤中的葡萄糖-6-磷酸脱氢酶平均活性高于良性肿瘤。含有雌二醇受体的肿瘤比没有受体的肿瘤具有更高的葡萄糖-6-磷酸脱氢酶活性。在有和没有雌二醇受体的乳腺癌中，葡萄糖-6-磷酸脱氢酶在聚丙烯酰胺凝胶电泳后产生3种同工酶，其电泳图谱非常相似。结果表明，尽管雌二醇受体阳性肿瘤中的葡萄糖-6-磷酸脱氢酶高于雌二醇受体阴性肿瘤，但在人类乳腺肿瘤中，雌二醇受体浓度与葡萄糖-6-磷酸脱氢酶活性之间没有显著相关性。
