Shimizu M, Saitoh Y, Ohyanagi H, Itoh H
First Department of Pathology, Kobe University School of Medicine, Hyogo, Japan.
Arch Pathol Lab Med. 1990 Feb;114(2):195-200.
In order to test the effectiveness of CA19-9, KM01, unabsorbed CEA (carcinoembryonic antigen) and absorbed CEA by immunoperoxidase staining, we evaluated the staining distribution, intensity, and cellular localization in pancreatic cancer. The results were then compared with those of normal pancreas and chronic pancreatitis. The positive staining rate of the pancreatic cancer with any of the four tumor markers was higher than that of the normal pancreas. However, all markers except absorbed CEA showed a higher positive staining rate for chronic pancreatitis than for pancreatic cancer. There was no stromal type in normal pancreatic or chronic pancreatitis tissues with any of the four tumor markers. Our findings, therefore, indicate that absorbed CEA is useful in differentiating pancreatic cancer from normal pancreatic tissues. It is not useful in distinguishing chronic pancreatitis, however, unless a specific staining pattern is observed.
为了通过免疫过氧化物酶染色检测CA19-9、KM01、未吸收的癌胚抗原（CEA）和吸收的CEA的有效性，我们评估了它们在胰腺癌中的染色分布、强度和细胞定位。然后将结果与正常胰腺和慢性胰腺炎的结果进行比较。四种肿瘤标志物中任何一种在胰腺癌中的阳性染色率均高于正常胰腺。然而，除吸收的CEA外，所有标志物在慢性胰腺炎中的阳性染色率均高于胰腺癌。正常胰腺或慢性胰腺炎组织中使用这四种肿瘤标志物均未出现间质类型。因此，我们的研究结果表明，吸收的CEA有助于区分胰腺癌与正常胰腺组织。然而，它在区分慢性胰腺炎方面并无用处，除非观察到特定的染色模式。
