Wang J Y, Chen F Z, Yang Y Z
Zhongshan Hospital, Shanghai Medical University.
Chin Med J (Engl). 1990 Oct;103(10):817-20.
Monoclonal antibody defined antigen (CA19-9), carcinoembryonic antigen (CEA), ultrasonography (US) and computerized tomography (CT) were carried out as the tests in 113 patients suspected to have pancreatic cancer. Of 98 patients who underwent operation, 55 were found to have pancreatic cancer, 25 benign pancreatic disease, and 18 cancer of the biliary tract. Follow-up study was carried out for more than 1 year in 15 other patients suffering from pancreatitis without surgical intervention. The accuracy of CA19-9, US, CEA and CT was 87%, 69%, 61% and 56% respectively. The sensitivity of each test was CA19-9, 98%; US, 89%; CT, 80%; and CEA, 38%. The sensitivity of parallel test combined with CA19-9 and CEA was 100%. It may be regarded as the first step to detect pancreatic cancer in suspected population. The specificity of each test was CEA, 82%; CA19-9, 76%; US, 50% and CT, 40%. And the specificity of serial tests combined with CA19-9 and US was 90%. When these two tests were both positive, pancreatic cancer was highly suspected.
对113例疑似胰腺癌患者进行了单克隆抗体定义抗原（CA19-9）、癌胚抗原（CEA）、超声检查（US）和计算机断层扫描（CT）检查。在98例接受手术的患者中，55例被诊断为胰腺癌，25例为胰腺良性疾病，18例为胆管癌。另外15例未接受手术干预的胰腺炎患者进行了超过1年的随访研究。CA19-9、US、CEA和CT的准确率分别为87%、69%、61%和56%。各项检查的敏感性分别为：CA19-9为98%；US为89%；CT为80%；CEA为38%。CA19-9和CEA联合平行试验的敏感性为100%。可将其视为在疑似人群中检测胰腺癌的第一步。各项检查的特异性分别为：CEA为82%；CA19-9为76%；US为50%；CT为40%。CA19-9和US联合系列试验的特异性为90%。当这两项检查均为阳性时，高度怀疑为胰腺癌。
