Liberzon Israel, Martis Brian
Trauma Stress and Anxiety Research Group, Department of Psychiatry, Ann Arbor VA Healthcare System, University of Michigan, 1500 E. Medical Center Drive UH9D 0118, Ann Arbor, MI 48109-0118, USA.
Ann N Y Acad Sci. 2006 Jul;1071:87-109. doi: 10.1196/annals.1364.009.
Neuroimaging research offers a powerful and noninvasive means to understand healthy as well as dysregulated emotional processing in healthy subjects and PTSD patients. Functional neuroimaging findings suggest specific roles for subregions of the medial prefrontal (mPFC), orbito frontal (OFC), anterior cingulate (ACC), and insular cortices as well as the sublenticular extended amygdala (SLEA) and hippocampus in various components of emotional processing. Some of the same regions appear to be associated with emotional response to trauma, and with symptom formation in PTSD. Neuroimaging findings of emotional processing in healthy subjects and PTSD patients are discussed, addressing the specific roles of cortical regions like mPFC, ACC, and insula, and their potential contribution to PTSD pathophysiology. Processes of cognitive-emotional interactions and social emotions are discussed in an attempt to synthesize the prefrontal findings in healthy subjects and PTSD patients. Further links between functional neuroanatomy of emotional responses and neuroendocrine stress regulation are proposed.
神经影像学研究提供了一种强大的非侵入性手段，用于了解健康受试者以及创伤后应激障碍（PTSD）患者的正常和失调情绪处理过程。功能性神经影像学研究结果表明，内侧前额叶（mPFC）、眶额叶（OFC）、前扣带回（ACC）、岛叶皮质以及豆状核下扩展杏仁核（SLEA）和海马体的亚区域在情绪处理的各个组成部分中发挥着特定作用。其中一些相同的区域似乎与对创伤的情绪反应以及PTSD的症状形成有关。本文讨论了健康受试者和PTSD患者情绪处理的神经影像学研究结果，阐述了诸如mPFC、ACC和岛叶等皮质区域的具体作用及其对PTSD病理生理学的潜在影响。为了综合健康受试者和PTSD患者前额叶的研究结果，本文还讨论了认知 - 情绪相互作用和社会情绪的过程。此外，还提出了情绪反应的功能性神经解剖学与神经内分泌应激调节之间的进一步联系。
