Frewen Paul A, Pain Claire, Dozois David J A, Lanius Ruth A
London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, Ontario, Canada, N6A 5A5.
Ann N Y Acad Sci. 2006 Jul;1071:397-400. doi: 10.1196/annals.1364.029.
Two studies examined correlates of alexithymia in posttraumatic stress disorder (PTSD). In study 1 (n = 77 individuals with PTSD and 45 controls) Toronto alexithymia scale (TAS-20) scores were positively correlated with PTSD symptoms, dissociation, and childhood abuse and neglect. In study 2, TAS-20 scores were examined as correlates of functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) response to trauma script imagery. In 16 controls, TAS-20 scores correlated positively with response in medial prefrontal cortex (mPFC), and negatively with response in anterior cingulate cortex (ACC) and thalamus. In 26 individuals with PTSD, TAS-20 scores correlated positively with response in insula, posterior cingulate cortex (PCC), and thalamus, and negatively with response in ACC.
两项研究探讨了创伤后应激障碍（PTSD）中述情障碍的相关因素。在研究1（77名PTSD患者和45名对照）中，多伦多述情障碍量表（TAS-20）得分与PTSD症状、解离以及童年期虐待和忽视呈正相关。在研究2中，TAS-20得分被作为功能磁共振成像（fMRI）对创伤脚本意象的血氧水平依赖（BOLD）反应的相关因素进行研究。在16名对照中，TAS-20得分与内侧前额叶皮质（mPFC）的反应呈正相关，与前扣带回皮质（ACC）和丘脑的反应呈负相关。在26名PTSD患者中，TAS-20得分与脑岛、后扣带回皮质（PCC）和丘脑的反应呈正相关，与ACC的反应呈负相关。
