Iverfeldt K, Solti M, Bartfai T
Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Brain Res. 1990 Jan 8;506(2):335-8. doi: 10.1016/0006-8993(90)91275-l.
Substance P (SP) and neurokinin A (NKA), two coexisting neuropeptides of the tachykinin family, stimulated the basal (5 mM K+) and evoked (40 mM K+) release of [3H]5-HT (5-hydroxytryptamine) from tissue slices of the rat cerebral cortex. Spantide ([DArg1,-DTrp7,9,Leu11]SP; 10(-5) M) inhibited the effects of SP but potentiated the effects of NKA. The effects of SP and NKA appear to be exerted at distinct receptors but involve a common post-receptor mechanism as no full additivity of the SP- and NKA-mediated stimulation of [3H]5-HT could be observed. The effects of the 3 tachykinins, SP, NKA and NKB, are compared with respect to stimulation of the release of [3H]5-HT.
P物质（SP）和神经激肽A（NKA）是速激肽家族中两种共存的神经肽，它们刺激了大鼠大脑皮质组织切片中基础状态（5 mM钾离子）和诱发状态（40 mM钾离子）下[3H]5-羟色胺（5-HT）的释放。Spantide（[DArg1,-DTrp7,9,Leu11]SP；10^(-5) M）抑制了SP的作用，但增强了NKA的作用。SP和NKA的作用似乎是通过不同的受体发挥的，但涉及共同的受体后机制，因为未观察到SP和NKA介导的[3H]5-HT刺激的完全相加作用。比较了三种速激肽SP、NKA和神经激肽B（NKB）对[3H]5-HT释放的刺激作用。
