Ricci L C, Wellman M M
Rhode Island College, Warwick.
J Clin Psychol. 1990 Jan;46(1):106-16. doi: 10.1002/1097-4679(199001)46:1<106::aid-jclp2270460117>3.0.co;2-3.
The purpose of this article is to give the clinician not proficient in biochemistry an understanding of the biochemical research data on neurotransmitters and suicide. This literature review reports the current findings on serotonin (5-HT), dopamine (DA), and norepinephrine (NE) as possible biochemical markers of depression and suicide. In conjunction with known environmental and behavioral indicators of suicide, neurotransmitter balance could be a factor in determining the severity of depression and the possible suicidal ideation in patients. Numerous studies have been performed on the monoamines: Serotonin, Dopamine and Norepinephrine, neurotransmitters that innervate parts of the spinal cord and all areas of the brain. Studies appear to suggest a relationship among monoamine levels, depression, and suicide. Significantly low levels of serotonin and the neurotransmitter metabolite (5-HIAA) may be correlated with suicidal behavior.
本文的目的是让不精通生物化学的临床医生了解有关神经递质与自杀的生化研究数据。这篇文献综述报告了目前关于血清素（5-羟色胺，5-HT）、多巴胺（DA）和去甲肾上腺素（NE）作为抑郁症和自杀可能的生化标志物的研究结果。结合已知的自杀环境和行为指标，神经递质平衡可能是决定抑郁症严重程度以及患者自杀意念的一个因素。针对单胺类物质（血清素、多巴胺和去甲肾上腺素，这些神经递质支配脊髓部分区域和大脑所有区域）已经开展了大量研究。研究似乎表明单胺水平、抑郁症和自杀之间存在关联。血清素和神经递质代谢物（5-羟吲哚乙酸，5-HIAA）的显著低水平可能与自杀行为相关。
