Lapointe Nicolas P, Ung Roth-Visal, Bergeron Maxime, Cote Martin, Guertin Pierre A
Neuroscience Unit, Laval University Medical Center, Quebec City, PQ, Canada.
Behav Neurosci. 2006 Aug;120(4):826-34. doi: 10.1037/0735-7044.120.4.826.
Reorganization and plasticity after spinal cord injury have been recently shown to take place in sublesional neuronal networks, but the possibility of strain-dependent changes at that level has never been explored. The authors studied the spontaneous return of hindlimb movement in low-thoracic spinal cord transected (Tx) mice from 3 commonly used strains. Without intervention, most CD1, C57BL/6, and BALB/c mice displayed some hindlimb movement recovery after Tx. Although all assessment methods unanimously reported that CD1 displayed higher recovery levels than did the C57BL/6 and BALB/c, higher scores were generally found with the Antri-Orsal-Barthe (M. Antri, D. Orsal, & J. Y. Barthe, 2002) and the Average Combined Score (P. A. Guertin, 2005a) methods. Such spontaneous recovery in low-thoracic Tx mice is likely the result of neuronal plasticity at the lumbosacral spinal cord level, suggesting that these sublesional changes are strain dependent.
脊髓损伤后的重组和可塑性最近已被证明发生在损伤平面以下的神经元网络中，但该水平上应变依赖性变化的可能性从未被探讨过。作者研究了来自3种常用品系的低胸段脊髓横断（Tx）小鼠后肢运动的自发恢复情况。未经干预，大多数CD1、C57BL/6和BALB/c小鼠在Tx后表现出一定程度的后肢运动恢复。尽管所有评估方法一致报告CD1的恢复水平高于C57BL/6和BALB/c，但通常使用Antri-Orsal-Barthe方法（M. Antri、D. Orsal和J. Y. Barthe，2002年）和平均综合评分方法（P. A. Guertin，2005a）时能得到更高的分数。低胸段Tx小鼠的这种自发恢复可能是腰骶脊髓水平神经元可塑性的结果，这表明这些损伤平面以下的变化是品系依赖性的。
